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In animal and cell models, GLP-1 has been shown to impact the development and/or progression of atherosclerotic plaques

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Indeed, the first pass effect, or the extent to which a drug is metabolized by intestinal, hepatic, and microbial enzymes, is ultimately what determines the bioavailability of a drug (how much reaches circulation) and is subject to considerable variability depending on the presence or absence of certain microbes and enzymes

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J Med Internet Res 23(1):e20491 Hernndez-Saavedra D, Hinkley JM, Baer LA, Pinckard KM, Vidal P, Nirengi S, Brennan AM, Chen EY, Narain NR, Bussberg V, Tolstikov VV (2024) Chronic exercise improves hepatic acylcarnitine handling